Regulators and Effectors of Small GTPases: Ras Family by William E. Balch,Channing J. Der,Alan Hall

By William E. Balch,Channing J. Der,Alan Hall

The Ras superfamily (>150 human individuals) encompasses Ras GTPases interested by mobilephone proliferation, Rho GTPases fascinated by regulating the cytoskeleton, Rab GTPases all for membrane targeting/fusion and a gaggle of GTPases together with Sar1, Arf, Arl and dynamin occupied with vesicle budding/fission. those GTPases act as molecular switches and their actions are managed through various regulatory molecules that have an effect on both GTP loading (guanine nucleotide trade elements or GEFs) or GTP hydrolysis (GTPase activating proteins or GAPs). of their energetic kingdom, they have interaction with a regularly expanding, functionally complicated array of downstream effectors.

Since the final Methods in Enzymology quantity in this subject in 2000, the learn of Ras relatives GTPases has witnessed a plethora of recent instructions and tendencies. as regards to the founding member of the Ras superfamily, the research of Ras in oncogenesis has visible the improvement and alertness of extra complicated version mobilephone tradition and animal platforms. the invention of mutationally activated B-Raf in human cancers has injected renewed curiosity during this classical effector pathway of Ras.

  • Includes a database for Ras kin proteins and their effectors and regulators
  • Complimentary to quantity 406 insurance of the Rho kinfolk
  • Over a hundred and fifty overseas contributors

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